23 June 2026
Polynucleotides are injectable treatments made from purified DNA fragments, usually sourced from salmon or trout, that aim to support the skin's own repair processes rather than add volume. They are often described as skin regenerators because they are thought to stimulate fibroblasts, the cells linked to collagen and elastin. This makes them different in intent from dermal fillers, which physically plump, and from hyaluronic acid skin boosters, which mainly hydrate. The evidence is promising but still developing, so a consultation with a qualified clinician is the right place to explore whether they suit you.
What are polynucleotides and how do they work?
Polynucleotides, sometimes called PN or PDRN, are chains of nucleotides (the building blocks of DNA) that are extracted and highly purified from fish sources such as salmon or trout. The purification process is designed to remove cellular material, leaving a sterile gel-like solution. Once injected into the skin, they are thought to act as biostimulators, signalling fibroblast activity and supporting hydration. The proposed mechanism involves adenosine receptor pathways that may influence inflammation and tissue repair.
Polynucleotides versus fillers and skin boosters
Dermal fillers are usually cross-linked hyaluronic acid gels used to add structure and volume to specific areas. Hyaluronic acid skin boosters focus on spreading hydration through the skin to improve glow and surface quality. Polynucleotides sit apart from both: the aim is regeneration and skin quality rather than volumising or purely hydrating. In practice, a clinician may discuss these options separately or as part of a wider plan, depending on your goals.
What does the current evidence suggest?
Published studies suggest polynucleotides may help with skin elasticity, texture and hydration, and they are generally reported as well tolerated. However, many studies are small, single-arm or of low to moderate quality, and long-term data beyond a few months remains limited. This means outcomes vary between individuals and cannot be guaranteed. Researchers broadly agree that larger, higher-quality trials are needed to standardise protocols and confirm comparative benefit.
Who might consider polynucleotides?
People sometimes explore polynucleotides when they are interested in overall skin quality, such as fine lines, dullness or crepey texture, rather than added volume. Common areas of interest include the face, under-eye area and neck. Suitability depends on your skin, medical history and expectations, and some people are not appropriate candidates. A qualified clinician can assess these factors, explain possible side effects such as temporary redness or swelling, and help you weigh the options.
Common questions
- Are polynucleotides the same as dermal filler?
- No. Dermal fillers are typically hyaluronic acid gels used to add volume and structure, whereas polynucleotides are intended to support the skin's own repair and quality without adding volume. They serve different purposes, and a clinician can explain which, if either, fits your goals.
- How long do polynucleotide results last?
- Reported outcomes vary between individuals, and robust long-term data is still limited. Many clinics describe a course of sessions followed by maintenance, but timelines and results are not guaranteed. A consultation is the best way to get realistic, personalised information.
- Are polynucleotide injections safe?
- Studies generally report that polynucleotides are well tolerated, with side effects such as temporary redness, swelling or bruising at injection sites. As with any injectable, risks exist and suitability differs person to person. Only a qualified clinician can assess your individual situation.